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The input to the system are single point missense events affecting the human kinome. Variants are defined by a Uniprot accession, a position in the protein and the wild-type and alternative amino acids. Consequently, a change from Valine to Glutamate in position 600 of the B-Raf proto-oncogene would be encoded as P15056 V600E.

Non-standard amino acids (B and Z) will be decomposed into separate instances of their standard counterparts (D, N and E, Q, respectively) whereas synonymous and truncating variants will be excluded from the analysis. Additionally, we highlight in red input instances where the introduced wild-type amino acid does not coincide with the expected equivalent position in the canonical protein sequence.